ea0032oc3.1 | Thyroid | ECE2013
Vitiello Michela
, Valentino Teresa
, De Menna Marta
, Serpico Luigia
, Mansueto Sonia
, Vita Gabriella De
, Fusco Alfredo
, Fedele Monica
PATZ1, a member of the POZ-ZF protein family of transcription factors is emerging as an important cancer-associated factor that can act either as oncogene or tumour-suppressor depending on the cellular context. Consistent with a tumour-suppressor role in thyroid cells, we have shown that PATZ1 is highly downregulated in anaplastic thyroid carcinomas compared to normal thyroid tissue and is a powerful inhibitor of anaplastic thyroid cancer cell survival, migration, invasiveness...